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NEJM: Selenium and the Course of Mild Graves’ Orbitopathy

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Claudio Marcocci, M.D., George J. Kahaly, M.D., Gerasimos E. Krassas, M.D., Luigi Bartalena, M.D., Mark Prummel, M.D., Matthias Stahl, M.D., Maria Antonietta Altea, M.D., Marco Nardi, M.D., Susanne Pitz, M.D., Kostas Boboridis, M.D., Paolo Sivelli, M.D., George von Arx, M.D., Maarten P. Mourits, M.D., Lelio Baldeschi, M.D., Walter Bencivelli, Ph.D., and Wilmar Wiersinga, M.D. for the European Group on Graves' Orbitopathy. N Engl J Med 2011, May 19. Link

This trial compared oral selenium, an antioxidant agent, or oral pentoxifylline, an antiinflammatory agent, with placebo in mild Graves’ orbitopathy. Selenium significantly improved quality of life and eye involvement and slowed disease progression...